The influence of Atlantic Niño on the following ENSO becomes significant since mid-1970’s. However, exact mechanisms for this inter-decadal change are still unclear. Here, we perform a set of model pacemaker experiments to probe relative contributions of the changes in the Atlantic Niño itself and the mean-state under global warming. The results suggest that the warmer background of the tropical Atlantic plays an essential role in enhancing local mean precipitation, inducing stronger divergence and low-level easterlies in the Pacific. Under a favorable condition in the Pacific, even a weak Atlantic Niño-related warming could promote the development of La Niña through cross-basin Walker circulation and the Indian Ocean-relayed Kelvin wave response. In contrast, the Atlantic Niño pattern change itself induces feeble convection anomalies in the western Atlantic, which cannot induce significant atmospheric response in the Pacific. These results imply an important modulation of global warming on the inter-basin connection.